Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans | Zendy

Xiuyun Li | Zendy; Yinglong Hou | Zendy; Long-Tao Yue | Zendy; Shuyuan Liu | Zendy; Juan Du | Zendy; Shujuan Sun | Zendy

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Potential Targets for Antifungal Drug Discovery Based on Growth and Virulence in Candida albicans

Author(s) -

Xiuyun Li,

Yinglong Hou,

Long-Tao Yue,

Shuyuan Liu,

Juan Du,

Shujuan Sun

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00726-15

Subject(s) - candida albicans , virulence , antifungal drug , antifungal drugs , corpus albicans , antifungal , biology , microbiology and biotechnology , drug , pharmacology , genetics , gene

Fungal infections, especially infections caused byCandida albicans , remain a challenging problem in clinical settings. Despite the development of more-effective antifungal drugs, their application is limited for various reasons. Thus, alternative treatments with drugs aimed at novel targets inC. albicans are needed. Knowledge of growth and virulence in fungal cells is essential not only to understand their pathogenic mechanisms but also to identify potential antifungal targets. This article reviews the current knowledge of the mechanisms of growth and virulence inC. albicans and examines potential targets for the development of new antifungal drugs.

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