Open AccessTolerance to the Glycopeptides Vancomycin and Teicoplanin in Coagulase-Negative Staphylococci
Author(s) -
Ingrid Bourgeois,
Martine Pestel-Caron,
Jean-François Lemeland,
Jean-Louis Pons,
François Caron
Publication year - 2007
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00719-06
Subject(s) - staphylococcus lugdunensis , teicoplanin , glycopeptide , coagulase , vancomycin , microbiology and biotechnology , cons , staphylococcus , biology , staphylococcus haemolyticus , staphylococcus aureus , antibiotics , bacteria , genetics , computer science , programming language
Tolerance to vancomycin and teicoplanin in 90 clinical isolates of coagulase-negative staphylococci (CoNS) was investigated by time-kill curve methodology. Only six strains, belonging to theStaphylococcus lugdunensis species, exhibited tolerance. The seven otherS. lugdunensis strains tested displayed weak susceptibility to the bactericidal activity of glycopeptides compared to the other CoNS. These phenomena are of concern, sinceS. lugdunensis is recognized as one of the most pathogenic CoNS.