Multiple Copies of qnrA1 on an IncA/C 2 Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant | Zendy

Laura Vinué | Zendy; Mohamad Sater | Zendy; Ian Herriott | Zendy; Miriam Huntley | Zendy; George A. Jacoby | Zendy; David C. Hooper | Zendy

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Multiple Copies of qnrA1 on an IncA/C ₂ Plasmid Explain Enhanced Quinolone Resistance in an Escherichia coli Mutant

Author(s) -

Laura Vinué,

Mohamad Sater,

Ian Herriott,

Miriam Huntley,

George A. Jacoby,

David C. Hooper

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00718-19

Subject(s) - plasmid , escherichia coli , minion , mutant , biology , microbiology and biotechnology , enterobacteriaceae , genetics , transposable element , gene , genome , nanopore sequencing

In a previous study, mutants with enhanced ciprofloxacin resistance (Cipr ) were selected fromEscherichia coli J53/pMG252 carryingqnrA1 . Strain J53 Cipr 8-2 showed an increase in the copy number and transcription level ofqnrA1 . We sequenced the plasmids on Illumina and MinION platforms.

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