Elevated Linezolid Resistance in Clinical cfr -Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3 | Zendy

Jeffrey B. Locke | Zendy; Gracia Morales | Zendy; M.T. Hilgers | Zendy; G. C. Kedar | Zendy; Shahad Rahawi | Zendy; Juan J. Picazo | Zendy; Karen Joy Shaw | Zendy; Jeffrey L. Stein | Zendy

Open Access

Elevated Linezolid Resistance in Clinical cfr -Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3

Author(s) -

Jeffrey B. Locke,

Gracia Morales,

M.T. Hilgers,

G. C. Kedar,

Shahad Rahawi,

Juan J. Picazo,

Karen Joy Shaw,

Jeffrey L. Stein

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00714-10

Subject(s) - 23s ribosomal rna , linezolid , staphylococcus aureus , ribosomal rna , microbiology and biotechnology , ribosomal protein , biology , genetics , bacteria , ribosome , gene , rna , vancomycin

Resistance to linezolid (LZD) occurs through mutations in 23S rRNA and ribosomal proteins L3 and L4 or through methylation of 23S rRNA by Cfr. Here we report novel L3 mutations, ΔSer145/His146Tyr and ΔMet169-Gly174, co-occurring with cfr in LZD-resistant Staphylococcus aureus isolates recovered from a hospital outbreak in Madrid, Spain. LZD MIC values (16, 32, or 64 μg/ml) correlated with the presence and severity of the L3 mutation. All isolates had TR-700 (torezolid) MIC values of ≤ 2 μg/ml.

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