Penicillin-Binding Protein Typing, Antibiotic Resistance Gene Identification, and Molecular Phylogenetic Analysis of Meropenem-Resistant Streptococcus pneumoniae Serotype 19A-CC3111 Strains in Japan | Zendy

Satoshi Nakano | Zendy; Takao Fujisawa | Zendy; Yutaka Ito | Zendy; Bin Chang | Zendy; Yasufumi Matsumura | Zendy; Masaki Yamamoto | Zendy; Shigeru Suga | Zendy; Makoto Ohnishi | Zendy; Miki Nagao | Zendy

Open Access

Penicillin-Binding Protein Typing, Antibiotic Resistance Gene Identification, and Molecular Phylogenetic Analysis of Meropenem-Resistant Streptococcus pneumoniae Serotype 19A-CC3111 Strains in Japan

Author(s) -

Satoshi Nakano,

Takao Fujisawa,

Yutaka Ito,

Bin Chang,

Yasufumi Matsumura,

Masaki Yamamoto,

Shigeru Suga,

Makoto Ohnishi,

Miki Nagao

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00711-19

Subject(s) - meropenem , serotype , streptococcus pneumoniae , microbiology and biotechnology , multilocus sequence typing , typing , penicillin , biology , pneumococcal infections , antibiotic resistance , antibiotics , virology , gene , genotype , genetics

Since the introduction of pneumococcal conjugate vaccines, the prevalence of non-meropenem-susceptible pneumococci has been increasing in Japan. In an earlier study, we demonstrated that multidrug-resistant serotype 15A-ST63 in Japan has a specificpbp1a sequence (pbp1a -13) that could promote meropenem resistance. To trace the origin ofpbp1a , we analyzed isolates of serotype 19A-CC3111, which is the most prevalent non-meropenem-susceptible clone in Japan.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research