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Many successful antimicrobial drugs originate from synthetic dyes. This paper reports thein vitro activity of 14 fluorescent dyes againstPlasmodium falciparum . Five of these dyes (Hoechst 33342, MitoRed, DiOC6 , SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against twoP. falciparum strains in the histidine-rich protein 2 drug sensitivity assay, while toxicity in HeLa cells is low. These dyes may be a starting point for developing new drugs againstP. falciparum .

In Vitro Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum