In Vitro Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum | Zendy

Fanny Joanny | Zendy; Jana Held | Zendy; Benjamin Mordmüller | Zendy

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In Vitro Activity of Fluorescent Dyes against Asexual Blood Stages of Plasmodium falciparum

Author(s) -

Fanny Joanny,

Jana Held,

Benjamin Mordmüller

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00709-12

Subject(s) - plasmodium falciparum , hela , in vitro , rhodamine , biology , fluorescence , rhodamine 123 , biochemistry , microbiology and biotechnology , chemistry , drug resistance , malaria , multiple drug resistance , immunology , physics , quantum mechanics

Many successful antimicrobial drugs originate from synthetic dyes. This paper reports thein vitro activity of 14 fluorescent dyes againstPlasmodium falciparum . Five of these dyes (Hoechst 33342, MitoRed, DiOC6 , SYTO 9, and rhodamine B) show activity at a low nanomolar concentration against twoP. falciparum strains in the histidine-rich protein 2 drug sensitivity assay, while toxicity in HeLa cells is low. These dyes may be a starting point for developing new drugs againstP. falciparum .

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