Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia | Zendy

Sami Hraiech | Zendy; Antoine Roch | Zendy; Hubert Lépidi | Zendy; Thérèse Atieh | Zendy; Gilles Audoly | Zendy; JeanMarc Rolain | Zendy; Didier Raoult | Zendy; Jean Michel Brunel | Zendy; Laurent Papazian | Zendy; Fabienne Brégeon | Zendy

Open Access

Impaired Virulence and Fitness of a Colistin-Resistant Clinical Isolate of Acinetobacter baumannii in a Rat Model of Pneumonia

Author(s) -

Sami Hraiech,

Antoine Roch,

Hubert Lépidi,

Thérèse Atieh,

Gilles Audoly,

JeanMarc Rolain,

Didier Raoult,

Jean Michel Brunel,

Laurent Papazian,

Fabienne Brégeon

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00700-13

Subject(s) - acinetobacter baumannii , colistin , biology , pneumonia , microbiology and biotechnology , virulence , acinetobacter , ventilator associated pneumonia , pseudomonas aeruginosa , antibiotics , bacteria , medicine , gene , genetics

We compared the fitness and lung pathogenicity of two isogenic clinical isolates of Acinetobacter baumannii, one resistant (ABCR) and the other susceptible (ABCS) to colistin. In vitro, ABCR exhibited slower growth kinetics than ABCS. In a rat model of pneumonia, ABCR was associated with less pronounced signs of infection (lung bacterial count, systemic dissemination, and lung damage) and a better outcome (ABCR and ABCS mortality rates, 20 and 50%, respectively [P = 0.03]).

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