The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans | Zendy

Guan-Yu Lin | Zendy; HsuehFen Chen | Zendy; Yao-Peng Xue | Zendy; Ying-Chieh Yeh | Zendy; Chia-Lu Chen | Zendy; Ming-Sun Liu | Zendy; WenChi Cheng | Zendy; ChungYu Lan | Zendy

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The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans

Author(s) -

Guan-Yu Lin,

HsuehFen Chen,

Yao-Peng Xue,

Ying-Chieh Yeh,

Chia-Lu Chen,

Ming-Sun Liu,

WenChi Cheng,

ChungYu Lan

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00699-16

Subject(s) - candida albicans , antimicrobial , microbiology and biotechnology , peptide , corpus albicans , antimicrobial peptides , antifungal , biofilm , biology , chemistry , bacteria , biochemistry , genetics

Two antimicrobial P-113 peptide derivatives, P-113Du and P-113Tri, were investigated in this study. Notably, P-113Du and P-113Tri contained significant fractions of α-helix conformation and were less sensitive to high salt and low pH than P-113. Moreover, compared to P-113, these peptides exhibited increased antifungal activity against planktonic cells, biofilm cells, and clinical isolates ofCandida albicans and non-albicans Candida spp. These results suggest that P-113Du and P-113Tri are promising candidates for development as novel antifungal agents.

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