In Vivo Efficacy of Anidulafungin against Mature Candida albicans Biofilms in a Novel Rat Model of Catheter-Associated Candidiasis | Zendy

Soňa Kucharíková | Zendy; Hélène Tournu | Zendy; Michelle Holtappels | Zendy; Patrick Van Dijck | Zendy; Katrien Lagrou | Zendy

Open Access

In Vivo Efficacy of Anidulafungin against Mature Candida albicans Biofilms in a Novel Rat Model of Catheter-Associated Candidiasis

Author(s) -

Soňa Kucharíková,

Hélène Tournu,

Michelle Holtappels,

Patrick Van Dijck,

Katrien Lagrou

Publication year - 2010

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00697-10

Subject(s) - anidulafungin , candida albicans , biofilm , microbiology and biotechnology , in vivo , echinocandins , biology , pharmacology , medicine , antifungal , fluconazole , bacteria , micafungin , caspofungin , genetics

The present study demonstrates the efficacy of anidulafungin on mature Candida albicans biofilms in vivo. One hundred fifty-seven catheter fragments challenged with C. albicans were implanted subcutaneously in rats. After formation of biofilms, rats were treated with daily intraperitoneal injections of anidulafungin for 7 days. Catheters retrieved from treated animals showed reduced cell numbers compared to those retrieved from untreated and fluconazole-treated animals. Systemic administration of anidulafungin is promising for the treatment of mature C. albicans biofilms.

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