Contribution of the Autolysin AtlA to the Bactericidal Activity of Amoxicillin against Enterococcus faecalis JH2-2 | Zendy

Anne-Lise Bravetti | Zendy; Stéphane Mesnage | Zendy; A. Lefort | Zendy; Françoise Chau | Zendy; Catherine Eckert | Zendy; Louis Garry | Zendy; Michel Arthur | Zendy; B. Fantin | Zendy

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Contribution of the Autolysin AtlA to the Bactericidal Activity of Amoxicillin against Enterococcus faecalis JH2-2

Author(s) -

Anne-Lise Bravetti,

Stéphane Mesnage,

A. Lefort,

Françoise Chau,

Catherine Eckert,

Louis Garry,

Michel Arthur,

B. Fantin

Publication year - 2009

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00692-08

Subject(s) - autolysin , amoxicillin , enterococcus faecalis , microbiology and biotechnology , streptococcaceae , antibiotics , endocarditis , in vitro , antibacterial agent , biology , chemistry , bacteria , medicine , biochemistry , staphylococcus aureus , surgery , streptococcus pneumoniae , genetics

The bactericidal activity of amoxicillin was investigated againstEnterococcus faecalis JH2-2 and against an isogenic mutant deficient in the production of theN -acetylglucosaminidase AtlA. Comparison of the two strains indicated that this autolysin contributes to killing by amoxicillin both in vitro and in a rabbit model of experimental endocarditis.

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