Open AccessContribution of the Autolysin AtlA to the Bactericidal Activity of Amoxicillin against Enterococcus faecalis JH2-2
Author(s) -
Anne-Lise Bravetti,
Michael P. Williamson,
A. Lefort,
Françoise Chau,
Catherine Eckert,
Louis Garry,
Michel Arthur,
Bruno Fantin
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00692-08
Subject(s) - autolysin , amoxicillin , enterococcus faecalis , microbiology and biotechnology , streptococcaceae , antibiotics , endocarditis , in vitro , antibacterial agent , biology , chemistry , bacteria , medicine , biochemistry , staphylococcus aureus , surgery , streptococcus pneumoniae , genetics
The bactericidal activity of amoxicillin was investigated againstEnterococcus faecalis JH2-2 and against an isogenic mutant deficient in the production of theN -acetylglucosaminidase AtlA. Comparison of the two strains indicated that this autolysin contributes to killing by amoxicillin both in vitro and in a rabbit model of experimental endocarditis.