Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa | Zendy

Erik Snesrud | Zendy; Rosslyn Maybank | Zendy; Yoon I. Kwak | Zendy; Anthony R. Jones | Zendy; Mary Hinkle | Zendy; Patrick McGann | Zendy

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Chromosomally Encoded mcr-5 in Colistin-Nonsusceptible Pseudomonas aeruginosa

Author(s) -

Erik Snesrud,

Rosslyn Maybank,

Yoon I. Kwak,

Anthony R. Jones,

Mary Hinkle,

Patrick McGann

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00679-18

Subject(s) - colistin , pseudomonas aeruginosa , broth microdilution , biology , transposable element , microbiology and biotechnology , whole genome sequencing , genome , mcr 1 , genetics , bacteria , gene , escherichia coli , enterobacteriaceae , antibiotics , minimum inhibitory concentration

Whole-genome sequencing (WGS) of historicalPseudomonas aeruginosa clinical isolates identified a chromosomal copy ofmcr-5 within a Tn3 -like transposon inP. aeruginosa MRSN 12280. The isolate was nonsusceptible to colistin by broth microdilution, and genome analysis revealed no mutations known to confer colistin resistance. To the best of our knowledge, this is the first report ofmcr in colistin-nonsusceptibleP. aeruginosa .

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