Activity of Imipenem-Relebactam and Comparator Agents against Genetically Characterized Isolates of Carbapenem-Resistant Enterobacteriaceae | Zendy

Matthew C. Canver | Zendy; Michael J. Satlin | Zendy; Lars F. Westblade | Zendy; Barry N. Kreiswirth | Zendy; Liang Chen | Zendy; Amy Robertson | Zendy; Kathy Fauntleroy | Zendy; Marisa La Spina | Zendy; Katrina Callan | Zendy; Stephen G. Jenkins | Zendy

Open Access

Activity of Imipenem-Relebactam and Comparator Agents against Genetically Characterized Isolates of Carbapenem-Resistant Enterobacteriaceae

Author(s) -

Matthew C. Canver,

Michael J. Satlin,

Lars F. Westblade,

Barry N. Kreiswirth,

Liang Chen,

Amy Robertson,

Kathy Fauntleroy,

Marisa La Spina,

Katrina Callan,

Stephen G. Jenkins

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00672-19

Subject(s) - enterobacteriaceae , carbapenem resistant enterobacteriaceae , imipenem , klebsiella pneumoniae , microbiology and biotechnology , biology , carbapenem , antimicrobial , antibiotics , antibiotic resistance , gene , escherichia coli , genetics

Carbapenem-resistantEnterobacteriaceae (CRE) strains are an urgent public health threat. We evaluated thein vitro activities of 19 antimicrobial agents, including imipenem-relebactam, against (i) 106 CRE bloodstream isolates that primarily expressedKlebsiella pneumoniae carbapenemase (KPC) and (ii) 20 OXA-48-like-expressing CRE isolates. Ninety-five percent of CRE bloodstream isolates were susceptible to imipenem-relebactam.

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