Efficacy of Ambruticin Analogs in a Murine Model of Coccidioidomycosis | Zendy

Lisa F. Shubitz | Zendy; John N. Galgiani | Zendy; Zong-Qiang Tian | Zendy; Ziyang Zhong | Zendy; Pieter Timmermans | Zendy; Leonard Katz | Zendy

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Efficacy of Ambruticin Analogs in a Murine Model of Coccidioidomycosis

Author(s) -

Lisa F. Shubitz,

John N. Galgiani,

Zong-Qiang Tian,

Ziyang Zhong,

Pieter Timmermans,

Leonard Katz

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00670-06

Subject(s) - coccidioides , potency , antifungal , in vitro , microbiology and biotechnology , coccidioides immitis , ratón , mycosis , biology , sterilization (economics) , immunology , pharmacology , medicine , biochemistry , monetary economics , economics , foreign exchange market , foreign exchange

Ambruticin S, an antifungal cyclopropyl-pyran acid, showed curative effects against murine coccidioidal infection. Two analogs of this compound with greater in vitro potency were tested against lethal murineCoccidioides infection. Both improved the survival of mice over that of controls; one resulted in near-sterilization of infection.

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