External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database | Zendy

Shufan Ge | Zendy; Ryan J. Beechinor | Zendy; Christoph P. Hornik | Zendy; Joseph F. Standing | Zendy; Kanecia O. Zimmerman | Zendy; Michael CohenWolkowiez | Zendy; Matthew M. Laughon | Zendy; Reese H. Clark | Zendy; Daniel González | Zendy

Open Access

External Evaluation of a Gentamicin Infant Population Pharmacokinetic Model Using Data from a National Electronic Health Record Database

Author(s) -

Shufan Ge,

Ryan J. Beechinor,

Christoph P. Hornik,

Joseph F. Standing,

Kanecia O. Zimmerman,

Michael CohenWolkowiez,

Matthew M. Laughon,

Reese H. Clark,

Daniel González

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00669-18

Subject(s) - gentamicin , electronic health record , pharmacokinetics , medicine , population , database , population pharmacokinetics , health records , pediatrics , antibiotics , computer science , environmental health , pharmacology , biology , health care , political science , law , microbiology and biotechnology

Gentamicin is a common antibiotic used in neonates and infants. A recently published population pharmacokinetic (PK) model was developed using data from multiple studies, and the objective of our analyses was to evaluate the feasibility of using a national electronic health record (EHR) database for further external evaluation of this model. Our results suggest that, with proper data capture procedures, EHR data can serve as a potential data source for external evaluation of PK models.

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