In Vitro Activity of Aurein 1.2 Alone and in Combination with Antibiotics against Gram-Positive Nosocomial Cocci | Zendy

Maria Carla Re | Zendy; Oscar Cirioni | Zendy; Alessandra Riva | Zendy; Wojciech Kamysz | Zendy; Carmela Silvestri | Zendy; Piotr Nadolski | Zendy; Agnese Della Vittoria | Zendy; Jerzy Łukasiak | Zendy; Giorgio Scalise | Zendy

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In Vitro Activity of Aurein 1.2 Alone and in Combination with Antibiotics against Gram-Positive Nosocomial Cocci

Author(s) -

Maria Carla Re,

Oscar Cirioni,

Alessandra Riva,

Wojciech Kamysz,

Carmela Silvestri,

Piotr Nadolski,

Agnese Della Vittoria,

Jerzy Łukasiak,

Giorgio Scalise

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00666-06

Subject(s) - gram positive cocci , antibiotics , microbiology and biotechnology , gram , in vitro , gram positive bacteria , biology , bacteria , chemistry , biochemistry , staphylococcus aureus , genetics

This study was performed to evaluate the in vitro activity of the amphibian peptide aurein 1.2 and to investigate its interaction with six antibiotics against nosocomial gram-positive cocci. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline.

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