In Vitro Activity of Bedaquiline and Delamanid against Nontuberculous Mycobacteria, Including Macrolide-Resistant Clinical Isolates | Zendy

Dae Hun Kim | Zendy; Byung Woo Jhun | Zendy; Seong Mi Moon | Zendy; SuYoung Kim | Zendy; Kyeongman Jeon | Zendy; O Jung Kwon | Zendy; Hee Jae Huh | Zendy; Nam Yong Lee | Zendy; Sung Jae Shin | Zendy; Charles L. Daley | Zendy; WonJung Koh | Zendy

Open Access

In Vitro Activity of Bedaquiline and Delamanid against Nontuberculous Mycobacteria, Including Macrolide-Resistant Clinical Isolates

Author(s) -

Dae Hun Kim,

Byung Woo Jhun,

Seong Mi Moon,

SuYoung Kim,

Kyeongman Jeon,

O Jung Kwon,

Hee Jae Huh,

Nam Yong Lee,

Sung Jae Shin,

Charles L. Daley,

WonJung Koh

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00665-19

Subject(s) - bedaquiline , nontuberculous mycobacteria , microbiology and biotechnology , in vitro , macrolide antibiotics , antibiotics , biology , mycobacterium , medicine , bacteria , tuberculosis , mycobacterium tuberculosis , erythromycin , pathology , biochemistry , genetics

We evaluated thein vitro activities of the antimicrobial drugs bedaquiline and delamanid against the major pathogenic nontuberculous mycobacteria (NTM). Delamanid showed high MIC values for all NTM exceptMycobacterium kansasii . However, bedaquiline showed low MIC values for the major pathogenic NTM, includingMycobacterium avium complex,Mycobacterium abscessus subsp.abscessus ,M. abscessus subsp.massiliense , andM. kansasii .

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