Klebsiella pneumoniae OmpA Confers Resistance to Antimicrobial Peptides | Zendy

Enrique Llobet | Zendy; Catalina March | Zendy; Paloma Giménez | Zendy; José A. Bengoechea | Zendy

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Klebsiella pneumoniae OmpA Confers Resistance to Antimicrobial Peptides

Author(s) -

Enrique Llobet,

Catalina March,

Paloma Giménez,

José A. Bengoechea

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00657-08

Subject(s) - klebsiella pneumoniae , microbiology and biotechnology , antimicrobial , enterobacteriaceae , biology , mutant , cytotoxicity , antibiotic resistance , klebsiella , escherichia coli , antibiotics , in vitro , gene , biochemistry

A Klebsiella pneumoniae ompA mutant was more susceptible to antimicrobial peptides (APs) than the wild type. Susceptibility did not result from surface changes other than the absence of OmpA. Our data suggest that OmpA is implicated in the activation of yet-unknown systems dedicated to ameliorating AP cytotoxicity.

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