Pyrazinamide Is Active against Mycobacterium tuberculosis Cultures at Neutral pH and Low Temperature | Zendy

Alice L. den Hertog | Zendy; Sandra Menting | Zendy; Richard F. Pfeltz | Zendy; Matthew Warns | Zendy; Salman H. Siddiqi | Zendy; Richard Anthony | Zendy

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Pyrazinamide Is Active against Mycobacterium tuberculosis Cultures at Neutral pH and Low Temperature

Author(s) -

Alice L. den Hertog,

Sandra Menting,

Richard F. Pfeltz,

Matthew Warns,

Salman H. Siddiqi,

Richard Anthony

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00654-16

Subject(s) - pyrazinamide , mycobacterium tuberculosis , tuberculosis , microbiology and biotechnology , chemistry , antibacterial agent , mechanism of action , in vitro , biology , medicine , biochemistry , antibiotics , pathology

For the past decades, an acidic pH has been used to render Mycobacterium tuberculosis susceptible to pyrazinamide for in vitro testing. Here, we show that at the standard breakpoint concentration and reduced culture temperatures, pyrazinamide (PZA) is active against tuberculosis (TB) at neutral pH. This finding should help unravel the mechanism of action of PZA and allow drug susceptibility testing (DST) methods to be optimized.

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