Identification and Characterization of Salmonella enterica Serotype Newport Isolates with Decreased Susceptibility to Ciprofloxacin in the United States | Zendy

Davina Campbell | Zendy; Kaitlin A. Tagg | Zendy; Amelia Bicknese | Zendy; Andre McCullough | Zendy; Jess Chen | Zendy; Beth E. Karp | Zendy; Jason P. Folster | Zendy

Open Access

Identification and Characterization of Salmonella enterica Serotype Newport Isolates with Decreased Susceptibility to Ciprofloxacin in the United States

Author(s) -

Davina Campbell,

Kaitlin A. Tagg,

Amelia Bicknese,

Andre McCullough,

Jess Chen,

Beth E. Karp,

Jason P. Folster

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00653-18

Subject(s) - salmonella enterica , ciprofloxacin , serotype , salmonella , quinolone , microbiology and biotechnology , biology , plasmid , virology , gene , antibiotics , genetics , bacteria

NontyphoidalSalmonella (NTS) causes an estimated 1.2 million illnesses, 23,000 hospitalizations, and 450 deaths each year in the United States. Decreased susceptibility to ciprofloxacin (DSC) has historically been associated with chromosomal mutations of the quinolone resistance determining region (QRDR), but plasmid-mediated quinolone resistance (PMQR) genes are increasing. To investigate DSC amongSalmonella enterica serotype Newport strains, we examined 40 isolates from 1996 to 2016 with DSC. Thirty isolates (71%) contained the PMQR geneqnrB and eight isolates (19%) contained a QRDR.

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