Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture | Zendy

Robin J. Svensson | Zendy; Wilber Sabiiti | Zendy; Gibson Kibiki | Zendy; Nyanda Elias Ntinginya | Zendy; Nilesh Bhatt | Zendy; Geraint Davies | Zendy; Stephen H. Gillespie | Zendy; Ulrika S. H. Simonsson | Zendy

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Model-Based Relationship between the Molecular Bacterial Load Assay and Time to Positivity in Liquid Culture

Author(s) -

Robin J. Svensson,

Wilber Sabiiti,

Gibson Kibiki,

Nyanda Elias Ntinginya,

Nilesh Bhatt,

Geraint Davies,

Stephen H. Gillespie,

Ulrika S. H. Simonsson

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00652-19

Subject(s) - ethambutol , pyrazinamide , sputum , tuberculosis , rifampicin , biomarker , sputum culture , medicine , mycobacterium tuberculosis , liquid culture , immunology , biology , pathology , biochemistry , botany

The molecular bacterial load (MBL) assay is a new tuberculosis biomarker which provides results in ∼4 hours. The relationship between MBL and time-to-positivity (TTP) has not been thoroughly studied, and predictive models do not exist. We aimed to develop a model for MBL and identify the MBL-TTP relationship in patients.

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