Mature Pseudomonas aeruginosa Biofilms Prevail Compared to Young Biofilms in the Presence of Ceftazidime | Zendy

Laura L. Bowler | Zendy; George G. Zhanel | Zendy; T. Blake Ball | Zendy; Laura Saward | Zendy

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Mature Pseudomonas aeruginosa Biofilms Prevail Compared to Young Biofilms in the Presence of Ceftazidime

Author(s) -

Laura L. Bowler,

George G. Zhanel,

T. Blake Ball,

Laura Saward

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00650-12

Subject(s) - ceftazidime , biofilm , pseudomonas aeruginosa , microbiology and biotechnology , ciprofloxacin , antibiotics , meropenem , gentamicin , bacteria , biology , pseudomonadaceae , pseudomonadales , antibiotic resistance , genetics

Phenotypic tolerances to antibiotics of mature and young Pseudomonas aeruginosa PAO1 biofilms and released planktonic bacteria were compared for four antibiotics. Resistance levels were similar for gentamicin and ciprofloxacin but differed for ceftazidime and meropenem. β-Lactamase mapping showed that, after 5 h of ceftazidime exposure, mature biofilms produced more β-lactamase than young biofilms, facilitating the growth of released planktonic bacteria. This shows the importance of early treatment and choice of antibiotics for P. aeruginosa biofilm infections.

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