Transcriptional Regulator TetR21 Controls the Expression of the Staphylococcus aureus LmrS Efflux Pump | Zendy

Q. C. Truong-Bolduc | Zendy; Julia Y. Wang | Zendy; Chuo Chen | Zendy; David C. Hooper | Zendy

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Transcriptional Regulator TetR21 Controls the Expression of the Staphylococcus aureus LmrS Efflux Pump

Author(s) -

Q. C. Truong-Bolduc,

Julia Y. Wang,

Chuo Chen,

David C. Hooper

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00649-17

Subject(s) - transcription (linguistics) , regulator , psychological repression , biology , mutant , staphylococcus aureus , microbiology and biotechnology , gene expression , genetics , gene , bacteria , philosophy , linguistics

TetR21 controls the expression of Tet38 and LmrS efflux pumps. AtetR21 mutant, QT21, exhibited a 4-fold increase in the transcription level oflmrS .Staphylococcus aureus lmrS overexpressor showed increases of 4-fold and 2-fold, respectively, in the MICs of chloramphenicol and erythromycin, while the MICs oflmrS mutant QT18 andlmrS-tetR21 mutant QT1821 remained similar to those of parental strain RN6390. TetR21 does not bind to the promoter oflmrS , suggesting indirect regulation oflmrS .

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