Efficacy of Tigecycline Alone and in Combination with Gentamicin in the Treatment of Experimental Endocarditis Due to Linezolid-Resistant Enterococcus faecium | Zendy

Konstantinos Pontikis | Zendy; Angelos Pefanis | Zendy; Θωμάς Τσαγανός | Zendy; IraMaria Tzepi | Zendy; Dionyssia-Pinelopi Carrer | Zendy; Helen Giamarellou | Zendy

Open Access

Efficacy of Tigecycline Alone and in Combination with Gentamicin in the Treatment of Experimental Endocarditis Due to Linezolid-Resistant Enterococcus faecium

Author(s) -

Konstantinos Pontikis,

Angelos Pefanis,

Θωμάς Τσαγανός,

IraMaria Tzepi,

Dionyssia-Pinelopi Carrer,

Helen Giamarellou

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00646-13

Subject(s) - tigecycline , linezolid , enterococcus faecium , gentamicin , endocarditis , enterococcus , medicine , microbiology and biotechnology , antibiotics , pharmacology , biology , vancomycin , staphylococcus aureus , bacteria , genetics

We evaluated the efficacy of tigecycline in a rabbit model of experimental endocarditis caused by a linezolid-resistant clinical strain of Enterococcus faecium. Tigecycline-treated animals had a 2.8-log10-CFU/g reduction in microbial counts in excised vegetations compared with controls. Addition of gentamicin caused a further arithmetical reduction in colony counts. The therapeutic effect was sustained 5 days after completion of treatment, as shown by relapse studies performed in treatment groups.

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