Metabolomics of Escherichia coli Treated with the Antimicrobial Carbon Monoxide-Releasing Molecule CORM-3 Reveals Tricarboxylic Acid Cycle as Major Target | Zendy

Sandra M. Carvalho | Zendy; Joana Marques | Zendy; Carlos C. Romão | Zendy; Lı́gia M. Saraiva | Zendy

Open Access

Metabolomics of Escherichia coli Treated with the Antimicrobial Carbon Monoxide-Releasing Molecule CORM-3 Reveals Tricarboxylic Acid Cycle as Major Target

Author(s) -

Sandra M. Carvalho,

Joana Marques,

Carlos C. Romão,

Lı́gia M. Saraiva

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00643-19

Subject(s) - escherichia coli , antimicrobial , citric acid cycle , carbon monoxide , tricarboxylic acid , metabolomics , chemistry , biochemistry , mode of action , metabolome , reactivity (psychology) , microbiology and biotechnology , combinatorial chemistry , biology , organic chemistry , metabolism , medicine , chromatography , alternative medicine , pathology , gene , catalysis

In the last decade, carbon monoxide-releasing molecules (CORMs) have been shown to act against several pathogens and to be promising antimicrobials. However, the understanding of the mode of action and reactivity of these compounds on bacterial cells is still deficient. In this work, we used a metabolomics approach to probe the toxicity of the ruthenium(II) complex Ru(CO)3 Cl(glycinate) (CORM-3) onEscherichia coli .

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