Open AccessIn Vitro Antianaerobic Activity of DX-619, a New Des-Fluoro(6)Quinolone
Author(s) -
Kaori Tanaka,
Hiroshige Mikamo,
Ken'ichi Nakao,
Kunitomo Watanabe
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00639-06
Subject(s) - imipenem , microbiology and biotechnology , bacteroides , quinolone , fusobacterium , in vitro , anaerobic bacteria , prevotella , chemistry , actinomyces , antibiotics , biology , bacteria , biochemistry , antibiotic resistance , genetics
Thein vitro activity of DX-619, a new des-F(6) quinolone, againstanaerobic bacteria was evaluated. DX-619 showed potent activity againstBacteroides ,Prevotella ,Fusobacterium ,Micromonas ,Actinomyces , andClostridium spp., with MIC50 s/MIC90 s of ≤0.03 to0.25/≤0.03 to 1 μg/ml, respectively. DX-619 was alsoactive against imipenem-resistantBacteroides spp., withMIC50 s/MIC90 s of 0.25/1 μg/ml,respectively.