A Novel Y319H Substitution in CYP51C Associated with Azole Resistance in Aspergillus flavus | Zendy

Raees A. Paul | Zendy; Shivaprakash M. Rudramurthy | Zendy; Jacques F. Meis | Zendy; Johan W. Mouton | Zendy; Arunaloke Chakrabarti | Zendy

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A Novel Y319H Substitution in CYP51C Associated with Azole Resistance in Aspergillus flavus

Author(s) -

Raees A. Paul,

Shivaprakash M. Rudramurthy,

Jacques F. Meis,

Johan W. Mouton,

Arunaloke Chakrabarti

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00637-15

Subject(s) - aspergillus flavus , voriconazole , azole , biology , microbiology and biotechnology , fungi imperfecti , aspergillus , mutation , gene , drug resistance , genetics , antifungal

This study aimed to explore any mutation in the CYP51 gene conferring azole resistance in Aspergillus flavus. Two voriconazole-resistant and 45 voriconazole-susceptible isolates were included in the study. Sequence analysis demonstrated a T1025C nucleotide change in CYP51C, resulting in the Y319H amino acid substitution in one resistant isolate. However, the earlier described T788G mutation in CYP51C conferring voriconazole resistance in A. flavus isolates was present in all isolates, irrespective of their susceptibility status.

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