High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram | Zendy

Matthieu Grégoire | Zendy; Éric Dailly | Zendy; Paul Le Turnier | Zendy; Denis Garot | Zendy; Thomas Guimard | Zendy; Louis Bernard | Zendy; Pierre Tattevin | Zendy; Yves-Marie Vandamme | Zendy; J. Hoff | Zendy; F. Lemaı̂tre | Zendy; MarieClémence Verdier | Zendy; Guillaume Deslandes | Zendy; Ronan Bellouard | Zendy; Véronique Sébille | Zendy; Anne Chiffoleau | Zendy; D. Boutoille | Zendy; Dominique Navas | Zendy; Nathalie Asseray | Zendy

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High-Dose Ceftriaxone for Bacterial Meningitis and Optimization of Administration Scheme Based on Nomogram

Author(s) -

Matthieu Grégoire,

Éric Dailly,

Paul Le Turnier,

Denis Garot,

Thomas Guimard,

Louis Bernard,

Pierre Tattevin,

Yves-Marie Vandamme,

J. Hoff,

F. Lemaı̂tre,

MarieClémence Verdier,

Guillaume Deslandes,

Ronan Bellouard,

Véronique Sébille,

Anne Chiffoleau,

D. Boutoille,

Dominique Navas,

Nathalie Asseray

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00634-19

Subject(s) - medicine , ceftriaxone , regimen , meningitis , dosing , population , dose , nomogram , renal function , liter , antibacterial agent , surgery , antibiotics , biology , microbiology and biotechnology , environmental health

High dosages of ceftriaxone are used to treat central nervous system (CNS) infections. Dosage adaptation according to the glomerular filtration rate is currently not recommended. Ceftriaxone pharmacokinetics (PK) was investigated by a population approach in patients enrolled in a French multicenter prospective cohort study who received high-dose ceftriaxone for CNS infection as recommended by French guidelines (75 to 100 mg/kg of body weight/day without an upper limit).

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