Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa | Zendy

Rasmus L. Marvig | Zendy; Mette Sofie Rousing Søndergaard | Zendy; Søren Damkiær | Zendy; Niels Høiby | Zendy; Helle Krogh Johansen | Zendy; Søren Molin | Zendy; Lars Jelsbak | Zendy

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Mutations in 23S rRNA Confer Resistance against Azithromycin in Pseudomonas aeruginosa

Author(s) -

Rasmus L. Marvig,

Mette Sofie Rousing Søndergaard,

Søren Damkiær,

Niels Høiby,

Helle Krogh Johansen,

Søren Molin,

Lars Jelsbak

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00630-12

Subject(s) - pseudomonas aeruginosa , azithromycin , 23s ribosomal rna , microbiology and biotechnology , cystic fibrosis , biology , ribosomal rna , mutation , antibiotics , bacteria , genetics , rna , gene , ribosome

The emergence of antibiotic-resistant Pseudomonas aeruginosa is an important concern in the treatment of long-term airway infections in cystic fibrosis patients. In this study, we report the occurrence of azithromycin resistance among clinical P. aeruginosa DK2 isolates. We demonstrate that resistance is associated with specific mutations (A2058G, A2059G, and C2611T in Escherichia coli numbering) in domain V of 23S rRNA and that introduction of A2058G and C2611T into strain PAO1 results in azithromycin resistance.

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