Posaconazole Combined with Amphotericin B, an Effective Therapy for a Murine Disseminated Infection Caused by Rhizopus oryzae | Zendy

M. Mar Rodríguez | Zendy; Carolina Serena | Zendy; Marçal Mariné | Zendy; F. Javier Pastor | Zendy; Josep Guarro | Zendy

Open Access

Posaconazole Combined with Amphotericin B, an Effective Therapy for a Murine Disseminated Infection Caused by Rhizopus oryzae

Author(s) -

M. Mar Rodríguez,

Carolina Serena,

Marçal Mariné,

F. Javier Pastor,

Josep Guarro

Publication year - 2008

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00628-08

Subject(s) - posaconazole , amphotericin b , rhizopus oryzae , zygomycosis , medicine , rhizopus , body weight , mucormycosis , pharmacology , mycosis , combination therapy , antifungal , immunology , biology , surgery , dermatology , food science , fermentation

In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.

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