Open AccessPosaconazole Combined with Amphotericin B, an Effective Therapy for a Murine Disseminated Infection Caused by Rhizopus oryzae
Author(s) -
M. Mar Rodríguez,
Carolina Serena,
Marçal Mariné,
Francisco Pastor,
Josep Guarro
Publication year - 2008
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00628-08
Subject(s) - posaconazole , amphotericin b , rhizopus oryzae , zygomycosis , medicine , rhizopus , body weight , mucormycosis , pharmacology , mycosis , combination therapy , antifungal , immunology , biology , surgery , dermatology , food science , fermentation
In a murine model of disseminated zygomycosis, low doses of amphotericin B (0.3 mg/kg body weight/day) combined with posaconazole (40 mg/kg/day) prolonged survival and reduced tissue burden with respect to that of controls and that of both drugs administered alone. Results were similar to those obtained with amphotericin B given alone at 0.8 mg/kg/day.