New MLSBResistance Geneerm(43) in Staphylococcus lentus | Zendy

Sybille Schwendener | Zendy; Vincent Perreten | Zendy

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New MLSBResistance Geneerm(43) in Staphylococcus lentus

Author(s) -

Sybille Schwendener,

Vincent Perreten

Publication year - 2012

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00627-12

Subject(s) - staphylococcus , microbiology and biotechnology , staphylococcus aureus , medicine , biology , bacteria , genetics

The search for a specific rRNA methylase motif led to the identification of the new macrolide, lincosamide, and streptogramin B resistance gene erm(43) in Staphylococcus lentus. An inducible resistance phenotype was demonstrated by cloning and expressing erm(43) and its regulatory region in Staphylococcus aureus. The erm(43) gene was detected in two different DNA fragments, of 6,230 bp and 1,559 bp, that were each integrated at the same location in the chromosome in several S. lentus isolates of human, dog, and chicken origin.

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