In Vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model | Zendy

Alexander J. Lepak | Zendy; Miao Zhao | Zendy; Karen Marchillo | Zendy; Jamie VanHecker | Zendy; David R. Andes | Zendy

Open Access

In Vivo Pharmacodynamics of Omadacycline against Staphylococcus aureus in the Neutropenic Murine Thigh Infection Model

Author(s) -

Alexander J. Lepak,

Miao Zhao,

Karen Marchillo,

Jamie VanHecker,

David R. Andes

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00624-19

Subject(s) - staphylococcus aureus , pharmacodynamics , in vivo , antibiotics , methicillin resistant staphylococcus aureus , medicine , microbiology and biotechnology , staphylococcal infections , antibacterial agent , pharmacology , biology , pharmacokinetics , bacteria , genetics

Omadacycline is a novel aminomethylcycline antibiotic with potent activity againstStaphylococcus aureus , including methicillin-susceptibleS. aureus (MSSA) and methicillin-resistantS. aureus (MRSA). We investigated the pharmacodynamic activity of omadacycline against 10 MSSA/MRSA strains in a neutropenic murine thigh model.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research