Antibiotic Resistance and Single-Nucleotide Polymorphism Cluster Grouping Type in a Multinational Sample of Resistant Mycobacterium tuberculosis Isolates | Zendy

Michael Brimacombe | Zendy; Manzour Hernando Hazbón | Zendy; Alifiya S. Motiwala | Zendy; David Alland | Zendy

Open Access

Antibiotic Resistance and Single-Nucleotide Polymorphism Cluster Grouping Type in a Multinational Sample of Resistant Mycobacterium tuberculosis Isolates

Author(s) -

Michael Brimacombe,

Manzour Hernando Hazbón,

Alifiya S. Motiwala,

David Alland

Publication year - 2007

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00619-07

Subject(s) - mycobacterium tuberculosis , biology , genetics , drug resistance , tuberculosis , single nucleotide polymorphism , antibiotic resistance , antibiotics , genotype , polymorphism (computer science) , microbiology and biotechnology , virology , gene , medicine , pathology

A single-nucleotide polymorphism-based cluster grouping (SCG) classification system for Mycobacterium tuberculosis was used to examine antibiotic resistance type and resistance mutations in relationship to specific evolutionary lineages. Drug resistance and resistance mutations were seen across all SCGs. SCG-2 had higher proportions of katG codon 315 mutations and resistance to four drugs.

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