Complex Class 1 Integron Carrying qnrB62 and bla VIM-2 in a Citrobacter freundii Clinical Isolate | Zendy

Jae Jin Lee | Zendy; MiNa Kim | Zendy; Kwang Seung Park | Zendy; Jung Hun Lee | Zendy; Asad Mustafa Karim | Zendy; Moonhee Park | Zendy; Ji Hwan Kim | Zendy; Sang Hee Lee | Zendy

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Complex Class 1 Integron Carrying qnrB62 and bla _VIM-2 in a Citrobacter freundii Clinical Isolate

Author(s) -

Jae Jin Lee,

MiNa Kim,

Kwang Seung Park,

Jung Hun Lee,

Asad Mustafa Karim,

Moonhee Park,

Ji Hwan Kim,

Sang Hee Lee

Publication year - 2016

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00614-16

Subject(s) - integron , citrobacter freundii , biology , efflux , context (archaeology) , plasmid , transposition (logic) , genetics , gene , gene cassette , microbiology and biotechnology , enterobacteriaceae , escherichia coli , paleontology , linguistics , philosophy

The coexistence ofqnrB62 andbla VIM-2 was detected in aCitrobacter clinical isolate. The reduced fluoroquinolone susceptibility is attributable toqnrB62 , mutations of quinolone-resistance-determining regions, and an efflux pump or pumps. The genetic context surrounding chromosomalqnrB62 was a novel complex class 1 integron (In1184::ISCR1 ::qnrB62 ) containing a unique gene array (bla VIM-2 -aacA4′-8 -gucD ). An 18-nucleotide deletion at the 3′ end of thepspA gene [pspA (Δ18 )], upstream ofqnrB62 , and an inverted repeat region (IRR2) were detected in In1184::ISCR1 ::qnrB62 , indicating past transposition events.

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