Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm | Zendy

Kasper Klein | Zendy; Rasmus Birkholm Grønnemose | Zendy; Martin Alm | Zendy; Karoline Sidelmann Brinch | Zendy; Hans Jørn Kolmos | Zendy; Thomas Emil Andersen | Zendy

Open Access

Controlled Release of Plectasin NZ2114 from a Hybrid Silicone-Hydrogel Material for Inhibition of Staphylococcus aureus Biofilm

Author(s) -

Kasper Klein,

Rasmus Birkholm Grønnemose,

Martin Alm,

Karoline Sidelmann Brinch,

Hans Jørn Kolmos,

Thomas Emil Andersen

Publication year - 2017

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00604-17

Subject(s) - staphylococcus aureus , biofilm , silicone , microbiology and biotechnology , antimicrobial , methicillin resistant staphylococcus aureus , catheter , micrococcaceae , chemistry , bacteria , biology , medicine , surgery , genetics , organic chemistry

Staphylococcus aureus is a major human pathogen in catheter-related infections. Modifying catheter material with interpenetrating polymer networks is a novel material technology that allows for impregnation with drugs and subsequent controlled release. Here, we evaluated the potential for combining this system with plectasin derivate NZ2114 in an attempt to design anS. aureus biofilm-resistant catheter. The material demonstrated promising antibiofilm properties, including properties against methicillin-resistantS. aureus , thus suggesting a novel application of this antimicrobial peptide.

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