Open AccessIn Vitro Activity of Tomopenem (CS-023/RO4908463) against Anaerobic Bacteria
Author(s) -
Kaori Tanaka,
Hiroshige Mikamo,
Ken'ichi Nakao,
Taku Ichiishi,
Tomio Goto,
Yuka Yamagishi,
Kunitomo Watanabe
Publication year - 2009
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00595-08
Subject(s) - doripenem , meropenem , carbapenem , microbiology and biotechnology , in vitro , bacteria , pharmacology , chemistry , antibiotics , biology , medicine , biochemistry , antibiotic resistance , genetics
The antianaerobic activity of tomopenem, a new longer-half-life parenteral carbapenem, was compared with other carbapenems. Tomopenem showed broad activity against 63 reference species. The activity of tomopenem against 293 clinical isolates was potent (MIC90 , 0.06 to 4 μg/ml) and comparable to those of meropenem and doripenem and more potent than that of panipenem.