In Vitro Activity of Ceftazidime-Avibactam and Aztreonam-Avibactam against OXA-48-Carrying Enterobacteriaceae Isolated as Part of the International Network for Optimal Resistance Monitoring (INFORM) Global Surveillance Program from 2012 to 2015 | Zendy

Krystyna M. Kazmierczak | Zendy; Patricia A. Bradford | Zendy; Gregory G. Stone | Zendy; Boudewijn L. M. de Jonge | Zendy; Daniel F. Sahm | Zendy

Open Access

In Vitro Activity of Ceftazidime-Avibactam and Aztreonam-Avibactam against OXA-48-Carrying Enterobacteriaceae Isolated as Part of the International Network for Optimal Resistance Monitoring (INFORM) Global Surveillance Program from 2012 to 2015

Author(s) -

Krystyna M. Kazmierczak,

Patricia A. Bradford,

Gregory G. Stone,

Boudewijn L. M. de Jonge,

Daniel F. Sahm

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00592-18

Subject(s) - aztreonam , enterobacteriaceae , avibactam , broth microdilution , ceftazidime/avibactam , carbapenem resistant enterobacteriaceae , ceftazidime , microbiology and biotechnology , biology , medicine , antibiotic resistance , antibiotics , minimum inhibitory concentration , bacteria , pseudomonas aeruginosa , escherichia coli , imipenem , biochemistry , genetics , gene

Enterobacteriaceae producing the Ambler class D OXA-48 carbapenemase, combined with additional resistance mechanisms, such as permeability defects or cocarriage of class A, B, or C β-lactamases, can become highly resistant to most β-lactams currently in use, including carbapenems. A total of 45,872Enterobacteriaceae clinical isolates collected in 39 countries as part of the International Network for Optimal Resistance Monitoring (INFORM) global surveillance study in 2012 to 2015 were tested for susceptibility to β-lactams and comparator agents using the Clinical and Laboratory Standards Institute broth microdilution methodology and screened for the presence of β-lactamases.

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