Open AccessPotency of Solithromycin against Fast- and Slow-Growing Chlamydial Organisms
Author(s) -
Leiqiong Gao,
Yao Wang,
Ziyu Hua,
Enmei Liu,
Li Shen
Publication year - 2018
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00588-18
Subject(s) - potency , secretion , effector , microbiology and biotechnology , chlamydia , vacuole , in vitro , biology , virology , chemistry , immunology , biochemistry , cytoplasm
Evidence is provided that solithromycin is a bactericidal against not only fast-growing chlamydial organisms but also those slowed by gamma interferon (IFN-γ)in vitro . At sublethal concentrations, Sol impedes homotypic fusion ofChlamydia -containing vacuoles and reduces secretion of the type III secretion (T3S) effector IncA.
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