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Evidence is provided that solithromycin is a bactericidal against not only fast-growing chlamydial organisms but also those slowed by gamma interferon (IFN-γ)in vitro . At sublethal concentrations, Sol impedes homotypic fusion ofChlamydia -containing vacuoles and reduces secretion of the type III secretion (T3S) effector IncA.

Potency of Solithromycin against Fast- and Slow-Growing Chlamydial Organisms