Open AccessMaribavir Antagonizes the Antiviral Action of Ganciclovir on Human Cytomegalovirus
Author(s) -
Sunwen Chou,
Gail I. Marousek
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00577-06
Subject(s) - ganciclovir , foscarnet , cidofovir , virology , cytomegalovirus , human cytomegalovirus , betaherpesvirinae , pharmacology , herpesviridae , biology , virus , viral disease
The cytomegalovirus (CMV) UL97 kinase inhibitor maribavir antagonized the anti-CMV effect of ganciclovir, increasing the ganciclovir 50% inhibitory concentration against a sensitive strain by up to 13-fold. Antiviral activities of foscarnet and cidofovir were unaffected by maribavir.
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