Synergistic Effect of 14-Alpha-Lipoyl Andrographolide and Various Antibiotics on the Formation of Biofilms and Production of Exopolysaccharide and Pyocyanin by Pseudomonas aeruginosa | Zendy

Xiang-Ping Zeng | Zendy; Xiangyang Liu | Zendy; Jiang Bian | Zendy; Gang Pei | Zendy; Huanqin Dai | Zendy; Steven W. Polyak | Zendy; Fuhang Song | Zendy; Li Ma | Zendy; Yuqiang Wang | Zendy; Lixin Zhang | Zendy

Open Access

Synergistic Effect of 14-Alpha-Lipoyl Andrographolide and Various Antibiotics on the Formation of Biofilms and Production of Exopolysaccharide and Pyocyanin by Pseudomonas aeruginosa

Author(s) -

Xiang-Ping Zeng,

Xiangyang Liu,

Jiang Bian,

Gang Pei,

Huanqin Dai,

Steven W. Polyak,

Fuhang Song,

Li Ma,

Yuqiang Wang,

Lixin Zhang

Publication year - 2011

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00575-10

Subject(s) - pyocyanin , pseudomonas aeruginosa , andrographolide , biofilm , microbiology and biotechnology , antibiotics , bacteria , chemistry , biology , biochemistry , quorum sensing , genetics

Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa.

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