Open AccessSynergistic Effect of 14-Alpha-Lipoyl Andrographolide and Various Antibiotics on the Formation of Biofilms and Production of Exopolysaccharide and Pyocyanin by Pseudomonas aeruginosa
Author(s) -
XiangPing Zeng,
Xiangyang Li,
Jiang Bian,
Gang Pei,
Huanqin Dai,
Steven W. Polyak,
Fuhang Song,
Li Ma,
Yuqiang Wang,
Lixin Zhang
Publication year - 2011
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.00575-10
Subject(s) - pyocyanin , pseudomonas aeruginosa , andrographolide , biofilm , microbiology and biotechnology , antibiotics , bacteria , chemistry , biology , biochemistry , quorum sensing , genetics
Pseudomonas aeruginosa produces a biofilm that provides the bacteria with an effective barrier against antibiotics. Here, we investigated the synergy of various antibiotics with 14-alpha-lipoyl andrographolide (AL-1), focusing upon synthesis of the biofilm. AL-1 also inhibited the production of the exopolysaccharide and pyocyanin components. We propose that AL-1 may potentially serve as a cotherapy to combat P. aeruginosa.