Clonal Background, Resistance Gene Profile, and Porin Gene Mutations Modulate In Vitro Susceptibility to Imipenem-Relebactam in Diverse Enterobacteriaceae | Zendy

Angela GomezSimmonds | Zendy; Stephania Stump | Zendy; Marla J. Giddins | Zendy; Medini K. Annavajhala | Zendy; AnneCatrin Uhlemann | Zendy

Open Access

Clonal Background, Resistance Gene Profile, and Porin Gene Mutations Modulate In Vitro Susceptibility to Imipenem-Relebactam in Diverse Enterobacteriaceae

Author(s) -

Angela GomezSimmonds,

Stephania Stump,

Marla J. Giddins,

Medini K. Annavajhala,

AnneCatrin Uhlemann

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00573-18

Subject(s) - enterobacteriaceae , klebsiella pneumoniae , porin , carbapenem resistant enterobacteriaceae , biology , microbiology and biotechnology , gene , imipenem , genetics , antibiotic resistance , virology , antibiotics , escherichia coli , bacterial outer membrane

Treatment options for carbapenem-resistantEnterobacteriaceae (CRE) are limited. WhileKlebsiella pneumoniae strains harboringbla KPC account for most CRE, recent evidence points to increasing diversification of CRE.

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