In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis | Zendy

Lucio VeraCabrera | Zendy; Eva López González | Zendy; Adrián Rendón | Zendy; Jorge OcampoCandiani | Zendy; Oliverio Welsh | Zendy; Víctor Manuel Velázquez-Moreno | Zendy; Sung Choi | Zendy; Carmen A. Molina-Torres | Zendy

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In Vitro Activities of DA-7157 and DA-7218 against Mycobacterium tuberculosis and Nocardia brasiliensis

Author(s) -

Lucio VeraCabrera,

Eva López González,

Adrián Rendón,

Jorge OcampoCandiani,

Oliverio Welsh,

Víctor Manuel Velázquez-Moreno,

Sung Choi,

Carmen A. Molina-Torres

Publication year - 2006

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00571-06

Subject(s) - nocardia brasiliensis , microbiology and biotechnology , mycobacterium tuberculosis , nocardia , tuberculosis , biology , minimum inhibitory concentration , in vitro , antibiotics , bacteria , medicine , nocardiosis , biochemistry , pathology , genetics

The in vitro activities of DA-7157, a novel oxazolidinone, against clinical isolates of Nocardia brasiliensis and Mycobacterium tuberculosis were determined. Equal MIC(50)s and MIC(90)s (0.25 and 0.5 microg/ml, respectively) were found for susceptible and multidrug-resistant isolates of M. tuberculosis. The N. brasiliensis isolates showed an MIC(90) of 1 microg/ml and an MIC(50) of 1 microg/ml. The DA-7157 prodrug, DA-7218, exhibited similar MICs for M. tuberculosis but fivefold-higher MICs for N. brasiliensis.

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