Methicillin-Resistant Staphylococcus aureus Grown on Vancomycin-Supplemented Screening Agar Displays Enhanced Biofilm Formation | Zendy

Wenjiao Chang | Zendy; Ding Ding | Zendy; ShanShan Zhang | Zendy; Yuanyuan Dai | Zendy; Qing Pan | Zendy; Huaiwei Lu | Zendy; Qingli Luo | Zendy; Jilong Shen | Zendy; Xiaoling Ma | Zendy

Open Access

Methicillin-Resistant Staphylococcus aureus Grown on Vancomycin-Supplemented Screening Agar Displays Enhanced Biofilm Formation

Author(s) -

Wenjiao Chang,

Ding Ding,

ShanShan Zhang,

Yuanyuan Dai,

Qing Pan,

Huaiwei Lu,

Qingli Luo,

Jilong Shen,

Xiaoling Ma

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00568-15

Subject(s) - biofilm , vancomycin , microbiology and biotechnology , brain heart infusion , staphylococcus aureus , agar , bacterial adhesin , micrococcaceae , biology , antibacterial agent , chemistry , bacteria , antibiotics , escherichia coli , biochemistry , genetics , gene

Brain heart infusion agar containing 3 mg/liter vancomycin (BHI-V3) was used to screen for heterogeneous vancomycin-intermediateStaphylococcus aureus (hVISA). There was markedly greater biofilm formation by isolates that grew on BHI-V3 than by strains that did not grow on BHI-V3. Increased biofilm formation by hVISA may be mediated by FnbA- and polysaccharide intercellular adhesin-dependent pathways, and upregulation ofatlA andsarA may also contribute to enhanced biofilm formation by hVISA upon prolonged exposure to vancomycin.

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