First Report of an OXA-48-Producing Multidrug-Resistant Proteus mirabilis Strain from Gaza, Palestine | Zendy

Liang Chen | Zendy; Nahed Al Laham | Zendy; Kalyan D. Chavda | Zendy; José R. Mediavilla | Zendy; Michael R. Jacobs | Zendy; Robert A. Bonomo | Zendy; Barry N. Kreiswirth | Zendy

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First Report of an OXA-48-Producing Multidrug-Resistant Proteus mirabilis Strain from Gaza, Palestine

Author(s) -

Liang Chen,

Nahed Al Laham,

Kalyan D. Chavda,

José R. Mediavilla,

Michael R. Jacobs,

Robert A. Bonomo,

Barry N. Kreiswirth

Publication year - 2015

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00565-15

Subject(s) - proteus mirabilis , microbiology and biotechnology , plasmid , biology , tetracycline , multiple drug resistance , gene , palestine , genetics , antibiotics , escherichia coli , history , ancient history

We report the first multidrug-resistant Proteus mirabilis strain producing the carbapenemase OXA-48 (Pm-OXA-48) isolated at Al-Shifa hospital in Gaza, Palestine. Draft genome sequencing of Pm-OXA-48 identified 16 antimicrobial resistance genes, encoding resistance to β-lactams, aminoglycosides, fluoroquinolones, phenicols, streptothricin, tetracycline, and trimethoprim-sulfamethoxazole. Complete sequencing of the bla(OXA-48)-harboring plasmid revealed that it is a 72 kb long IncL/M plasmid, harboring carbapenemase gene bla(OXA-48), extended spectrum β-lactamase gene bla(CTX-M-14), and aminoglycoside resistance genes strA, strB, and aph(3')-VIb.

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