Efficacy of Amphotericin B at Suboptimal Dose Combined with Voriconazole in a Murine Model of Aspergillus fumigatus Infection with PoorIn VivoResponse to the Azole | Zendy

Marcelo SandovalDenis | Zendy; F. Javier Pastor | Zendy; Javier Capilla | Zendy; Josep Guarro | Zendy

Open Access

Efficacy of Amphotericin B at Suboptimal Dose Combined with Voriconazole in a Murine Model of Aspergillus fumigatus Infection with PoorIn VivoResponse to the Azole

Author(s) -

Marcelo SandovalDenis,

F. Javier Pastor,

Javier Capilla,

Josep Guarro

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00563-13

Subject(s) - voriconazole , aspergillus fumigatus , azole , amphotericin b , aspergillosis , medicine , microbiology and biotechnology , mycosis , pharmacology , antifungal , biology , immunology

The combination of amphotericin B at a suboptimal dose (0.3 mg/kg) with voriconazole has shown efficacy in prolonging survival and reducing tissue burden in a murine model of disseminated infection by an isolate ofAspergillus fumigatus that had showed a poorin vivo response to the azole. The efficacy of the combined treatment was higher than that obtained with amphotericin B at 0.8 mg/kg.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research