ClpA and HtpX Proteases Are Involved in Intrinsic Aminoglycoside Resistance of Stenotrophomonas maltophilia and Are Potential Aminoglycoside Adjuvant Targets | Zendy

Hsin-Hui Huang | Zendy; Yi-Tsung Lin | Zendy; Peng-Ying Chen | Zendy; Li-Hua Li | Zendy; Hsiao-Chen Ning | Zendy; TsueyChing Yang | Zendy

Open Access

ClpA and HtpX Proteases Are Involved in Intrinsic Aminoglycoside Resistance of Stenotrophomonas maltophilia and Are Potential Aminoglycoside Adjuvant Targets

Author(s) -

Hsin-Hui Huang,

Yi-Tsung Lin,

Peng-Ying Chen,

Li-Hua Li,

Hsiao-Chen Ning,

TsueyChing Yang

Publication year - 2018

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00554-18

Subject(s) - aminoglycoside , stenotrophomonas maltophilia , kanamycin , proteases , microbiology and biotechnology , biology , antibiotics , pseudomonas aeruginosa , genetics , biochemistry , bacteria , enzyme

The linkage of the protease-chaperon system, SmeYZ pump, and aminoglycoside resistance was assessed inStenotrophomonas maltophilia . TheclpA ,clpS ,clpP , andhtpX genes were upregulated in response to kanamycin exposure. Of these,clpA andhtpX were the primary determinants responsible for intrinsic aminoglycoside (AG) resistance. Inactivation ofclpA andhtpX compromised protease-mediated intrinsic aminoglycoside resistance and weakened SmeYZ pump-mediated aminoglycoside resistance, signifying HtpX and ClpA as potential AG adjuvant targets for treatment ofS. maltophilia infections.

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