Molecular Surveillance of Drug Resistance of Plasmodium falciparum Isolates Imported from Angola in Henan Province, China | Zendy

Ruimin Zhou | Zendy; Chengyun Yang | Zendy; Suhua Li | Zendy; Yuling Zhao | Zendy; Ying Liu | Zendy; Dan Qian | Zendy; Hao Wang | Zendy; Deling Lu | Zendy; Hongwei Zhang | Zendy; Fang Huang | Zendy

Open Access

Molecular Surveillance of Drug Resistance of Plasmodium falciparum Isolates Imported from Angola in Henan Province, China

Author(s) -

Ruimin Zhou,

Chengyun Yang,

Suhua Li,

Yuling Zhao,

Ying Liu,

Dan Qian,

Hao Wang,

Deling Lu,

Hongwei Zhang,

Fang Huang

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00552-19

Subject(s) - artemisinin , plasmodium falciparum , nonsynonymous substitution , malaria , drug resistance , piperaquine , biology , virology , sanger sequencing , mutation , genetics , gene , immunology , genome

Angola was the main origin country for the imported malaria in Henan Province, China. Antimalarial drug resistance has posed a threat to the control and elimination of malaria. Several molecular markers were confirmed to be associated with the antimalarial drug resistance, such aspfcrt ,pfmdr1 ,pfdhfr ,pfdhps , andK13. This study evaluated the drug resistance of the 180 importedPlasmodium falciparum isolates from Angola via nested PCR using Sanger sequencing.

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