Impact of Species Diversity on the Design of RNA-Based Diagnostics for Antibiotic Resistance in Neisseria gonorrhoeae | Zendy

Crista B. Wadsworth | Zendy; Mohamad Sater | Zendy; Roby P. Bhattacharyya | Zendy; Yonatan H. Grad | Zendy

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Impact of Species Diversity on the Design of RNA-Based Diagnostics for Antibiotic Resistance in Neisseria gonorrhoeae

Author(s) -

Crista B. Wadsworth,

Mohamad Sater,

Roby P. Bhattacharyya,

Yonatan H. Grad

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00549-19

Subject(s) - neisseria gonorrhoeae , biology , antibiotic resistance , antibiotics , computational biology , drug resistance , rna , phenotype , genetic diversity , microbiology and biotechnology , genetics , gene , medicine , population , environmental health

Quantitative assessment of antibiotic-responsive RNA transcripts holds promise for a rapid point-of-care (POC) diagnostic tool for antimicrobial susceptibility testing. These assays aim to distinguish susceptible and resistant isolates by transcriptional differences upon drug exposure. However, an often-overlooked dimension of designing these tests is that the genetic diversity within a species may yield differential transcriptional regulation independent of resistance phenotype.

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