Elevated Prevalence of Azole-Resistant Aspergillus fumigatus in Urban versus Rural Environments in the United Kingdom | Zendy

Thomas R. Sewell | Zendy; Yuyi Zhang | Zendy; Amelie P. Brackin | Zendy; Jennifer M. G. Shelton | Zendy; Johanna Rhodes | Zendy; Matthew C. Fisher | Zendy

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Elevated Prevalence of Azole-Resistant Aspergillus fumigatus in Urban versus Rural Environments in the United Kingdom

Author(s) -

Thomas R. Sewell,

Yuyi Zhang,

Amelie P. Brackin,

Jennifer M. G. Shelton,

Johanna Rhodes,

Matthew C. Fisher

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00548-19

Subject(s) - aspergillus fumigatus , azole , microbiology and biotechnology , fungi imperfecti , environmental health , biology , medicine , antifungal

Azole resistance in the opportunistic pathogenAspergillus fumigatus is increasing, dominated primarily by the following two environmentally associated resistance alleles: TR34 /L98H and TR46 /Y121F/T289A. By sampling soils across the South of England, we assess the prevalence of azole-resistantA. fumigatus (ARAf ) in samples collected in both urban and rural locations.

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