Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance | Zendy

John T. Williams | Zendy; Elizabeth R. Haiderer | Zendy; Garry B. Coulson | Zendy; Kayla N. Conner | Zendy; Edmund L. Ellsworth | Zendy; Chao Chen | Zendy; Nadine Álvarez | Zendy; Wei Li | Zendy; Mary Jackson | Zendy; Thomas Dick | Zendy; Robert B. Abramovitch | Zendy

Open Access

Identification of New MmpL3 Inhibitors by Untargeted and Targeted Mutant Screens Defines MmpL3 Domains with Differential Resistance

Author(s) -

John T. Williams,

Elizabeth R. Haiderer,

Garry B. Coulson,

Kayla N. Conner,

Edmund L. Ellsworth,

Chao Chen,

Nadine Álvarez,

Wei Li,

Mary Jackson,

Thomas Dick,

Robert B. Abramovitch

Publication year - 2019

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00547-19

Subject(s) - mutant , biology , mycolic acid , biochemistry , mycobacterium , genetics , gene , bacteria

TheMycobacterium tuberculosis mycolate flippase MmpL3 has been the proposed target for multiple inhibitors with diverse chemical scaffolds. This diversity in chemical scaffolds has made it difficult to predict compounds that inhibit MmpL3 without whole-genome sequencing of isolated resistant mutants.

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