Pharmacokinetics of a Multipurpose Pod-Intravaginal Ring Simultaneously Delivering Five Drugs in an Ovine Model | Zendy

John A. Moss | Zendy; Amanda Malone | Zendy; Thomas J. Smith | Zendy; Sean Kennedy | Zendy; Cali Nguyen | Zendy; Kathleen L. Vincent | Zendy; Massoud Motamedi | Zendy; Marc M. Baum | Zendy

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Pharmacokinetics of a Multipurpose Pod-Intravaginal Ring Simultaneously Delivering Five Drugs in an Ovine Model

Author(s) -

John A. Moss,

Amanda Malone,

Thomas J. Smith,

Sean Kennedy,

Cali Nguyen,

Kathleen L. Vincent,

Massoud Motamedi,

Marc M. Baum

Publication year - 2013

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.00547-13

Subject(s) - nevirapine , pharmacokinetics , pharmacology , medicine , progestin , tenofovir , vaginal ring , estrogen , human immunodeficiency virus (hiv) , family planning , virology , antiretroviral therapy , population , viral load , research methodology , environmental health

Multipurpose technologies that simultaneously protect from sexually transmitted infections and unintended pregnancy are urgently needed. Pod-intravaginal rings (IVRs) formulated with the antiretroviral agents (ARVs) tenofovir, nevirapine, and saquinavir and the contraceptives etonogestrel and estradiol were evaluated in sheep. Steady-state concentrations were maintained for 28 days with controlled, sustained delivery. This proof-of-principle study demonstrates that pod IVRs can deliver three ARVs from different mechanistic classes and a progestin-estrogen combination over the wide range needed for putative preventative efficacy.

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